Call us at from 8 AM - 2 AM EST to get great deals!

Book Flights from Charlotte to Knoxville will help you to find the best deals on flights from Charlotte to Knoxville. With our search technology, effortlessly searching flight routes across hundreds of airlines has never been easier or more convenient. With, we aim to make it simple and quick to search, select and save on the flights that best suit your needs and budget.

No matter if you are traveling for business or pleasure, we offer a wide range of deals from business class discounts to last minute flight deals to destinations like Knoxville. Whether you are planning ahead or looking for last minute tickets, CheapOair has the right flights at the right price. After booking your ticket, explore this page to view blog posts about this destination, learn more about hotels near TYS and read reviews from others who booked their flights with

Frequently Asked Questions - Charlotte to Knoxville Flights

  • When does the first flight of the day depart from CLT?

    7:45AM American Airlines Flight #807

  • When does the last flight depart to TYS?

    10:10PM American Airlines Flight #5072

  • What is the travel distance between Charlotte and Knoxville?

    180 miles

  • How many weekly flights are there between CLT to TYS?

    There are 32 weekly flights between CLT and TYS.

  • How many daily flights fly between Charlotte and Knoxville?

    There are 4 daily flights between CLT and TYS

  • Which is the busiest day in terms of passengers traffic between CLT to TYS?


  • Which is the nearest airport to Knoxville, Tennessee?

    McGhee Tyson Airport

  • Which is the nearest airport to Charlotte, North Carolina?

    Charlotte Douglas International Airport