Find great value on flights from Orlando to Buffalo with CheapOair! Buffalo is the second largest city in the state of New York. Buffalo city is located in the vicinity of the world popular Niagara Falls. Located on the shores of Lake Erie, the city is home to eclectic art galleries, world-renowned architecture, and plenty of famous universities. Visit Buffalo Museum of Science to view exhibits on Ecology of the Niagara Frontier, relax at Buffalo and Erie County Botanical Gardens, local wildlife at the 23.5-acre Buffalo Zoo, and visit the Ira G. Ross Aerospace Museum showcasing western New York's aerospace and aviation heritage via a wide variety of artifacts. Whatever type of vacation you are looking for, CheapOair will help you save big on flights to Buffalo!